Addressing the Challenges of C difficile Infection (CDI) in IBD: Strategies for Effective Prevention and Treatment

Addressing the Challenges of C difficile Infection (CDI) in IBD: Strategies for Effective Prevention and Treatment

On-Demand Webcast

David Binion, MD, FACG
University of Pittsburgh
Pittsburgh, Pennsylvania


Francis A. Farraye, MD, MSc, FACG
Boston Medical Center
Boston University School of Medicine
Boston, Massachusetts

Constantine Tsigrelis, MD
Cleveland Clinic
Cleveland Clinic Lerner College of Medicine
Cleveland, Ohio

Target Audience

This activity is intended for IBD specialists, gastroenterologists, GI fellows, and other healthcare professionals (internists, primary care physicians, nurse practitioners, physician assistants, nurses, pharmacists, etc) involved and/or interested in the therapeutic management of patients with IBD.


Clostridium difficile infection (CDI) is a cause of morbidity and mortality in the United States, and the incidence and severity of CDI has increased in recent years. The CDC has designated C difficile as 1 of 3 pathogens considered to be lethal and CDI as an urgent antibiotic resistance threat. In patients with inflammatory bowel disease (IBD), CDI has a more progressive disease course and incurs higher morbidity and mortality, increased hospitalizations, and increased need for surgical intervention, resulting in clinical management challenges. Because the clinical presentations of CDI and IBD with colitis overlap to a large extent, diagnosis is challenging. It is difficult to differentiate an IBD flare from CDI symptoms, and this contributes to a delay in CDI treatment for many patients with IBD.

This webcast addresses clinical practice gaps related to: making a CDI diagnosis, optimal guideline-directed co-treatment of CDI and IBD, and managing recurrent CDI in IBD.


Upon successful completion of this educational activity, participants should be better able to:

  1. Employ guideline recommendations for the diagnosis of CDI in patients with IBD
  2. Outline the factors that contribute to the difficulty in treating CDI in patients with IBD
  3. Discuss therapeutic strategies to reduce the risk of recurrence of CDI in patients with IBD

Release Date: December 21, 2018

Expiration Date: December 21, 2019

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to


Supported by an educational grant from: Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.


Imedex is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians.


In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.



Imedex designates this live activity for a maximum of 1.25 AMA PRA Category 1 Credits™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 1.25 AAPA Category 1 credits.

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 1.25 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.25 contact hours.


This knowledge-based activity (JA0006201-9999-18-246-H01-P/JA0006201-9999-19-112-H01-P) is approved for 1.25 contact hours (0.125 CEUs) of continuing pharmacy education.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact the Manager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Planning Committee

The planning committee comprises David Binion, MD, FACG, Francis A. Farraye, MD, MSc, FACG and Constantine Tsigrelis, MD; and Chris Bolwell, Manjusha Sala, Monalisa Singh, and Susan Yarbrough, Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

David Binion, MD, FACG has received research and/or grant support from AbbVie, Merck, Shire, and Takeda, and has served as a consultant for AbbVie, Janssen Biotech and Merck.

Francis A. Farraye, MD, MSc, FACG has served as a consultant for Braintree, Ferring, Innovation, Janssen, Lilly, Merck, Pfizer, Protagonist, and Takeda.

Constantine Tsigrelis, MD does not report any affiliation.

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Manjusha Sala, Monalisa Singh and Susan Yarbrough disclosed no relevant financial relationships with any commercial interests.

NACCME and Imedex require faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

Disclosure of off-label/unapproved uses of drugs and/or devices will be provided prior to the symposium.

Privacy Policy

NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. NACCME and our joint sponsors will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2018 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.