Looking for One in a Million: Is MRD the New Primary Goal for Multiple Myeloma Treatment?

Looking for One in a Million: Is MRD the New Primary Goal for Multiple Myeloma Treatment?

On-Demand Webcast

Suzanne Lentzsch, MD, PhD
Columbia University
Medical Center
New York, New York


C. Ola Landgren, MD, PhD
Memorial Sloan Kettering Cancer Center
New York, New York

Ajai Chari, MD
Icahn School of Medicine at Mount Sinai
New York, New York

Target Audience

Designed for hematologists and hematologic oncologists, medical, radiation, and surgical oncologists, and other healthcare professionals (e.g., physicians, physicians-in-training, oncology nurses, nurse practitioners, pharmacists, physician assistants) who are involved and/or interested in the treatment of patients with hematologic malignancies.


Minimal residual disease (MRD, sometimes also called measurable residual disease) has emerged as a vital marker for measuring recurrence and improved response rates in numerous hematological malignancies. MRD-based quantification of remaining diseased cells after treatment has been completed, has in recent years been incorporated into many phase 3 clinical trials across hematologic malignancies as an endpoint for regulatory approval. Moreover, until recently, precise and accurate technology for measuring and defining MRD-negative status has lagged behind the development of treatments that have been effective in achieving that status. Thus, with the evolving clinical data pool surrounding the quantification of MRD in MM, healthcare professionals who treat patients with hematologic malignancies require targeted education to ensure a thorough understanding of the benefits of setting MRD negativity as a trial endpoint and treatment goal.

This on-demand web archive is initiated to address such MRD-related knowledge and practice gaps among physicians, NPs, and PAs who manage patients with hematologic malignancies as well as to increased their awareness of the tools available to quantify it.

  1. Articulate the rationale for using MRD negativity as a new outcomes goal of treatment as well as an endpoint for clinical trials in MM
  2. Differentiate NGS and next-generation flow cytometry (NGF) from earlier-generation tests

Release Date: October 31, 2018

Expiration Date: October 31, 2019

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to webmaster@naccme.com.


Supported by an educational grant from Adaptive Biotechnologies.


Imedex is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians.


In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.



NACCME designates this live activity for a maximum of 0.50 AMA PRA Category 1 Credit™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 0.50 AAPA Category 1 credits.

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 0.50 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 0.50 contact hour.


This knowledge-based activity (JA0006201-9999-18-217-H01-P) is approved for 0.50 contact hour (0.005 CEUs) of continuing pharmacy education.

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Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

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Planning Committee

The planning committee comprises Ruben Niesvizky, MD, C.Ola Landgren, MD, PhD, Ajai Chari, MD and Suzanne Lentzsch, MD, PhD; and Chris Bolwell, Monalisa Singh, and Susan Yarbrough, Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Ajai Chari, MD has received research and/or grant support from Array Biopharm, Celgene, Janssen, Novartis and Takeda, has served as a consultant for Amgen, The Binding Site, Bristol-Myers Squibb, Celgene, Janssen, Novartis, and Takeda, and has received other support from Adaptive Biotechology, Novartis, and Takeda.

C. Ola Landgren, MD, PhD has no financial relationships to disclose.

Suzanne Lentzsch, MD, PhD has received research and/or grant support from Sanofi, has served as a consultant to Bayer, Caelum Bioscience and Janssen, owns stock in Caelum Biosciences, and has recieved other support from Caelum Biosciences

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Monalisa Singh and Susan Yarbrough disclosed no relevant financial relationships with any commercial interests.

NACCME and Imedex require faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

Disclosure of off-label/unapproved uses of drugs and/or devices will be provided prior to the symposium.

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Copyright © 2018 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.