FLT3 Targets in R/R AML: Evaluating Emerging Clinical Data and Implications on Current Practice

FLT3 Targets in R/R AML: Evaluating Emerging Clinical Data and Implications on Current Practice

On-Demand Webcast
Chair and Moderator

Gail J. Roboz, MD
Weill Cornell Medicine
New York, New York


Sangmin Lee, MD
Weill Cornell Medicine
New York, New York

Koen von Besien, MD, PhD
Weill Cornell Medicine
New York, New York

Target Audience

Designed for hematologists and hematologic oncologists, medical, radiation, and surgical oncologists, and other healthcare professionals (e.g., physicians, physicians-in-training, oncology nurses, nurse practitioners, pharmacists, physician assistants) who are involved and/or interested in the treatment of patients with hematologic malignancies.


In 2018, an estimated 19,520 new cases of acute myeloid leukemia (AML) will be diagnosed and approximately 10,670 deaths will be attributed to AML—representing the leading cause of mortality among all leukemias. While high complete response (CR) rates in AML are achievable, the majority of patients will ultimately be diagnosed with relapsed or refractory disease. The management of relapsed/refractory (R/R) AML imposes significant challenges to practice as cure rates no greater than 10% have been documented. A number of novel targeted agents have shown promise within the treatment of patient populations with FLT3-mutation positive R/R disease. However, gaps in provider knowledge may preclude their proper use within clinical practice once available.

This on-demand web archive is initiated to address such R/R AML-related knowledge and practice gaps among physicians, NPs, and PAs who manage patients with hematologic malignancies.

  1. Identify the challenges associated with the treatment of R/R AML, including mechanisms of resistance, molecular and cytogenic aberrations, and patient age/fitness
  2. Describe the mechanisms and genetic targets involved in hematologic neoplasms and AML in particular
  3. Evaluate clinical evidence and outcomes data surrounding new and emerging targeted therapies for the treatment in R/R AML
  4. Integrate new and emerging targeted agents into personalized R/R AML treatment plans

Release Date: October 31, 2018

Expiration Date: October 31, 2019

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to webmaster@naccme.com.


Supported by educational grants from AbbVie, Inc. and Astellas Pharma.


Imedex is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians.


In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.



NACCME designates this live activity for a maximum of 1.50 AMA PRA Category 1 Credits™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 1.50 AAPA Category 1 credit(s).

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 1.50 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.50 contact hours.


This knowledge-based activity (JA0006201-9999-18-214-H01-P) is approved for 1.50 contact hours (0.015 CEUs) of continuing pharmacy education.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact the Manager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Senior Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Planning Committee

The planning committee comprises Gail J. Roboz, MD, Sangmin Lee, MD and Koen von Besien, MD, PhD and Chris Bolwell, Monalisa Singh, and Susan Yarbrough, Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Gail J. Roboz, MD has received research and/or grant support from Cellectis, and has served as a consultant for AbbVie, Amphivena, Argenx, Astellas,Astex, Bayer, Celgene, Celltrion, Daiichi Sankyo, Eisai, Helsinn, Janssen, Jazz, Mei Pharma and Novartis.

Sangmin Lee, MD has no financial relationships to disclose.

Koen van Besien, MD, PhD has served as a consultant for Hemogenyx and Pfizer.

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Monalisa Singh and Susan Yarbrough disclosed no relevant financial relationships with any commercial interests.

NACCME and Imedex require faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

Disclosure of off-label/unapproved uses of drugs and/or devices will be provided prior to the symposium.

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Copyright © 2018 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.