New and Emerging Agents in ALL and the Evolving Treatment Paradigm

New and Emerging Agents in ALL and the Evolving Treatment Paradigm

On-Demand Webcast
Chair and Moderator

Gail J. Roboz, MD
Weill Cornell Medicine
New York, New York


Pinkal Desai, MD
Weill Cornell Medicine
New York, New York

Koen van Besien, MD, PhD
Weill Cornell Medicine
New York, New York

Target Audience

Designed for hematologists and hematologic oncologists, medical, radiation, and surgical oncologists, and other healthcare professionals (e.g., physicians, physicians-in-training, oncology nurses, nurse practitioners, pharmacists, physician assistants) who are involved and/or interested in the treatment of patients with hematologic malignancies.


Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer, predominantly affecting children aged 5 years and under, though the prevalence of ALL rises again in adults over 50 years of age. The heterogeneity of ALL generates unique challenges for optimal therapeutic approaches based on patient age, genetic aberrations, and treatment-related parameters such as the achievement of minimal residual disease (MRD) negativity. Moreover, certain patient subsets are refractory to traditional chemotherapeutic approaches, and the majority of patients who do respond will eventually relapse. New and emerging targeted therapies—including tyrosine kinase inhibitors (TKIs), monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and bispecific T-cell engagers (BiTEs)—offer new hope for improved outcomes in high-risk or relapsed/refractory (R/R) ALL patients. However, the emergence of these novel therapeutic approaches and outcomes measures such as MRD also generate new challenges with regards to implementation in clinical practice and creates knowledge gaps.

This on-demand web archive is initiated to address such ALL-related knowledge and practice gaps among physicians, NPs, and PAs who manage patients with hematologic malignancies.

  1. Describe the clinical-, disease-, and treatment-related factors that influence ALL prognosis and treatment outcomes 
  2. Define the role of minimum residual disease (MRD) in measuring ALL treatment outcomes and utility in clinical practice 
  3. Assess the preclinical and clinical evidence supporting the use of new and emerging targeted therapies in difficult-to-treat/high-risk ALL
  4. Consider the role of new and emerging targeted agents within the ALL treatment paradigm

Release Date: October 31, 2018

Expiration Date: October 31, 2019

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to


Supported by an educational grant from AbbVie, Inc.


Imedex is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.



NACCME designates this live activity for a maximum of 1.25 AMA PRA Category 1 Credits™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 1.25 AAPA Category 1 credits.

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 1.25 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.25 contact hours.


This knowledge-based activity (JA0006201-9999-18-213-H01-P) is approved for 1.25 contact hours (0.0125 CEUs) of continuing pharmacy education.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact theManager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Senior Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Planning Committee

The planning committee comprises Gail J. Roboz, MD, Pinkal Desai, MD and Koen van Besien, MD, PhD; and Chris Bolwell, Monalisa Singh, and Susan Yarbrough, Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Gail J. Roboz, MD has received research and/or grant support from Cellectis, and has served as a consultant for AbbVie, Amphivena, Argenx, Astellas,Astex, Bayer, Celgene, Celltrion, Daiichi Sankyo, Eisai, Helsinn, Janssen, Jazz, Mei Pharma and Novarits

Pinkal Desai, MD has served as a consultant for Cellerant

Koen van Besien, MD, PhD has served as a consultant for Hemogenyx and Pfizer.

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Monalisa Singh and Susan Yarbrough disclosed no relevant financial relationships with any commercial interests.

NACCME and Imedex require faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

Disclosure of off-label/unapproved uses of drugs and/or devices will be provided prior to the symposium.

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Copyright © 2018 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.