New Research and Clinical Applications: Activating Acute Wound Healing Response in Venous Leg Ulcers with Living Cell Based Therapy

New Research and Clinical Applications: Activating Acute Wound Healing Response in Venous Leg Ulcers with Living Cell Based Therapy

On-Demand Webcast

Paul J. Kim, DPM, MS
Professor of Plastic Surgery
Professor of Orthopedic Surgery
Medical Director, Wound Program
University of Texas Southwestern Clements University Hospital

Marjana Tomic-Canic, PhD
Professor and Vice Chair of Research
Director, Wound Healing and Regenerative Medicine Research Program
Department of Dermatology and Cutaneous Surgery Human Genetics and Genomics
Molecular and Cellular Pharmacology
University of Miami Miller School of Medicine

George J. Koullias, MD
Associate Professor of Surgery, Department of Surgery
Division of Vascular and Endovascular Surgery
Stony Brook University Hospital and Stony Brook Southampton Hospital
Stony Brook School of Medicine

Intended Learners

This activity is designed for physicians, podiatrists, nurse practitioners and physician assistants involved in the treatment of patients with chronic wounds.

Learning Objectives

After completing this activity, participants should be able to:

  • Discuss how to optimize the effectiveness of cell-based therapies by decreasing protease levels with appropriate wound site preparation
  • Investigate late-breaking science behind living cell-based therapy shifting chronic non-healing venous leg ulcers into an acute wound healing response
  • Explore cases of patients treated with living cell-based therapy combined with standard of care
Activity Overview

This on-demand webcast is available with synchronized slides and audio.

To be eligible for documentation of credit, participants must complete the educational activity, complete the 10-question post-test with a score of 70% or better, and complete the evaluation form. After successful completion of the post-test and evaluation form online at, participants may immediately print their documentation of credit.

Release date: November 29, 2018
Expiration date: November 29, 2020
Estimated time to complete: 1 hour

There is no fee associated with this activity.

For questions regarding this educational activity, please call 609-371-1137.


 In support of improving patient care, North American Center for Continuing Medical Education (NACCME) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


NACCME designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


This continuing nursing education activity awards 1.0 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.0 contact hour.

CPME Accreditation

North American Center for Continuing Medical Education, LLC (NACCME) is approved by the Council on Podiatric Medical Education as a provider of continuing education in podiatric medicine.

NACCME has approved this activity for a maximum of 1.0 continuing education contact hour.


NACCME has been authorized by the American Academy of PAs (APA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 1 AAPA Category 1 credit.

PAs should only claim credit commensurate with the extent of their participation.

Planning Committee

The planning committee comprises Daniel G. Federman, MD, Susie Seaman, NP; and Raquel Gaerlan, Marissa Grossman, Tiffney Oliver, Randy Robbin, and Susan Yarbrough, NACCME.

Independent Clinical Reviewer: Daniel G. Federman, MD, Associate Chief of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut

Nurse Planner: Susie Seaman, NP, Sharp Rees-Stealy Wound Clinic, San Diego, California

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

The faculty has reported the following:

Dr. Kim: Consultant—Acelity, Integra LifeSciences; Grant/Research Support—Acelity, Integra LifeSciences; Speakers' Bureau—Acelity, Integra LifeSciences
Dr. Koullias: Advisory Board—Organogenesis Inc; Speakers' Bureau—Organogenesis Inc
Ms. Seaman: Speakers' Bureau—BSCI, CSI
Dr. Tomic-Canic: 
Consultant—Organogenesis Inc.; Grant/Research Support—MV Tissue, Inc; Advisory Board—Molnlycke Health Care

Dr. Federman disclosed no relevant financial relationships with any relevant commercial interests

Marissa Grossman is a shareholder of Stabiliz Orthopaedics. Her spouse is an officer and board member of Stabiliz Orthopaedics.  Stabiliz Orthopaedics is not supporting this activity, nor does any content relate to their product/service.

Raquel Gaerlan, Tiffney Oliver, Randy Robbin, and Susan Yarbrough have disclosed no relevant financial relationships with any commercial interest.

NACCME requires faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

The faculty have disclosed the following: no off-label/unapproved uses of drugs and/or devices will be discussed in the presentation. 

Hardware/Software Requirements

All educational activities are accessible via a PC (Windows 2000/XP/Vista/7) or Mac (Mac OS 10.x or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. Windows Media Player or compatible alternative, sound card, and speakers are required for streamed audio. The latest version of the Adobe Flash Player is suggested for video programs (please download here). A PDF reader is required for print publications. Please direct technical questions to

Privacy Policy

NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. NACCME and our joint sponsors will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2018 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.

Grant Support

Supported by an educational grant from Organogenesis, Inc.