Personalized Precision Approaches in Multiple Myeloma: A Focus on Proteasome Inhibitors

Personalized Precision Approaches in Multiple Myeloma: A Focus on Proteasome Inhibitors

On-Demand Webcast

Kenneth C. Anderson, MD
Director, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute
Kraft Family Professor of Medicine, Harvard Medical School
Boston, Massachusetts

Noa Biran, MD
Assistant Professor
John Theurer Cancer Center
Hackensack Meridian Health
Hackensack, New Jersey

Morton Coleman, MD
Voluntary Faculty
Weill Cornell Medicine
New York, New York

Faith E. Davies, MD
Director, Myeloma Clinical Program
Perlmutter Cancer Center
NYU Grossman School of Medicine
New York, New York

Irene Ghobrial, MD
Director, Clinical Investigator Research Program
Dana-Farber Cancer Institute
Boston, Massachusetts

Suzanne Lentzsch, MD, PhD
Professor of Medicine Director of the Multiple Myeloma and Amyloidosis Program
Columbia University Medical Center
New York, New York

Elisabet E. Manasanch, MD
Associate Professor
MD Anderson Cancer Center
The University of Texas
Houston, Texas

Tomer M. Mark, MD, MSc
Associate Professor of Medicine
University of Colorado - Anschutz Medical Campus
Aurora, Colorado

María-Victoria Mateos, MD, PhD
Director of the Myeloma Unit
University Hospital of Salamanca
Salamanca, Spain

Joseph R. Mikhael, MD, MEd, FRCPC
Professor, Applied Cancer Research and Drug Discovery
City of Hope Cancer Center
Translational Genomics Research Institute
Phoenix, Arizona

Nikhil C. Munshi, MD
Director of Basic and Correlative Science
Jerome Lipper Multiple Myeloma Center
Dana-Farber Cancer Institute
Boston, Massachusetts

Ruben Niesvizky, MD
Professor of Medicine
Weill Cornell Medicine
New York, New York


Provided by North American Center for Continuing Medical Education, LLC (NACCME), an HMP Company.

For questions regarding this educational activity, please call 609-371-1137 or email


This educational activity is specifically designed for hematologists/oncologists, physician assistants, nurse practitioners, nurses, and pharmacists who specialize in hematology, as well as other healthcare providers who care for patients with hematologic malignancies.


Multiple myeloma (MM), a clonal B-cell malignancy characterized by the over-production of monoclonal immunoglobulin (M-protein), is the second most frequent hematological malignancy in the world, affecting 1-5 per 100,000 individuals per year, though the incidence varies regionally. Although considerable progress in the management of MM has been made over the last decade, many unmet needs remain, both in understanding the disease and its various underlying etiologies and in considerations for optimal clinical care. The 5-year relative survival of patients with MM is just 53.9% and the disease trajectory typically involves cycling through response, remission, and relapse, with diminishing depth and duration of response over time and the eventual progression to treatment-refractory relapse and death. Heterogenous chromosomal abnormalities are a prominent feature of MM, though the mechanisms that mediate genomic instability and clonal evolution are not well understood. This is of particular concern in the relapsed or refractory (R/R) setting where patients have typically acquired increasing subclonal heterogeneity, drug resistance, and toxicities. However, major strides toward understanding the pathophysiologof MM have given rise to a number of novel agents with unique therapeutic targets, mechanisms of action (MOAs), and potential for therapeutic combinations. New and emerging proteasome inhibitors (PIs) in particular have become a foundation of MM management, and the clinical data for this drug class is continually evolving. However, clinicians are now confronted with a large field of possible treatment combinations, and must consider varying mechanisms of action, toxicity profiles, adverse events (AEs) and patient factors when selecting and sequencing treatments. Healthcare providers (HCPs) involved in the management of R/R MM require up-to-date education on new and emerging treatment options and clinical trial results, including safety and efficacy profiles in order to develop innovative strategies to improve patient care.

This webcast aims to fill the gaps surrounding the use of proteasome inhibitors and other novel treatments for the management of multiple myeloma and precursor disorders.


After participating in this activity, learners should be better able to:

  • Translate recent clinical data concerning the role of PIs in MM management to real-world clinical practice 
  • Identify myeloma precursor disorders and evaluate the considerations for treatment 
  • Evaluate new and emerging therapies for R/R MM, including mechanisms of action, efficacy, and safety  
  • Develop treatment strategies for R/R MM that incorporate novel therapeutic targets and combinations for patients with resistance and toxicities from prior treatments  
  • Anticipate, prevent, and manage adverse events during R/R MM treatment   

To be eligible for credit, participants must complete the online activity and the evaluation. Upon completing the activity, there will be instructions on how to complete the evaluation and print a certificate or other documentation of credit.

Release Date: November 16, 2020
Expiration Date: November 16, 2021
Estimated Time to Complete: 3.75 hours

There is no fee associated with this activity.


Supported by educational grants from: Takeda Oncology



In support of improving patient care, NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


NACCME designates this internet enduring activity for a maximum of 3.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.


This continuing nursing education activity awards 3.75 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 3.75 contact hours. 


This internet enduring, knowledge-based activity (Universal Activity Number: JA0006201-0000-20-206-H01-P) has been approved for a maximum of 3.75 contact hours (.375 CEUs).

The certificate is not the official record of your participation in the activity. The official record of credit will be the information in the CPE Monitor system. Following ACPE Policy, NACCME must transmit your claim to CPE Monitor within 60 days from the date you complete this CPE activity. NACCME is not able to report your claimed credit after this 60-day period. Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 3.75 AAPA Category 1 credits. PAs should only claim credit commensurate with the extent of their participation.


This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of NACCME.


The material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither NACCME nor any of its subsidiaries or affiliates is affiliated with, or formally endorsed by a medical society.

The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME or HMP. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.


NACCME, LLC is an independent provider(s) of continuing medical education. NACCME, LLC has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

NACCME, LLC assures that all educational materials are reviewed to ensure for the absence of commercial bias, fair balance, scientific objectivity, and levels of evidence. The educational activity will not be influenced by commercial organizations and will not conflict with any other scheduled educational activities.

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

Planning Committee

In addition to the faculty listed below, NACCME planners and staff include Christopher Bolwell, Samantha Conforti, Mary Johnson, Randy Robbin, Greaton Sellers, Shannon Stevenson, and Griselda Zuccarino-Catania. 

Christopher Bolwell is a shareholder of GlaxoSmithKline. GlaxoSmithKline is not supporting this activity, nor does any content relate to their products or services.

Griselda Zuccarino-Catania disclosed that her spouse is employed by Janssen Pharmaceuticals, Inc.

No other planner has disclosed a relevant financial relationship with any commercial interest.


The faculty has reported the following:

Kenneth Anderson: Consultant-Amgen, BMS, Gilead, Janssen, Pfizer, Sanofi, Takeda

Noa Biran: Advisory Board-BMS, Janssen Pharmaceuticals; Consultant-BMD, Janssen Pharmaceuticals; Grant/Research Support-Janssen Pharmaceuticals, Karyopharm, Merck; Speakers Bureau-Janssen Pharmaceuticals 

Morton Coleman: Funded Research/Investigator-Acerta, Adagene, Beigene, Innocare, ARCUS Biosciences, AstraZeneca Pharmaceuticals LP, BMS (Celgene Coporation), Boston BioMedical, Inc., Eli Lilly and Company, EMD Serono Research and Development Institute, Inc., Genentech (F. Hoffman-LaRoche Ltd), GSK, Hutchinson MediPharma, LTD, Incyte Corporation, Ipsen Group, Karyopharm Therapeutics, Inc., Klus Pharma, Inc., MeiPharma, Inc., Merck Sharp & Dohme Corp., Novartis Pharmaceuticals, Seattle Genetics 

Faith Davies: Advisory Board-Amgen, BMS, Celege, Genentech/Roche, Janssen, Oncopeptide, Sanofi, Takeda; Consultant-Adaptive Biotechnologies, BMS, Celgene, Janssen, Oncopeptide; Grant/Research Support-BMS, Celgene, Janssen 

Irene Ghobrial: Advisory Board-Takeda, BMS, GSK, Janssen, Sanofi 

Suzanne Lentzsch: Advisory Board-Janssen Pharmaceuticals; Consultant-Caelum Bioscience, Janssen Pharmaceuticals, Sanofi, Sorrento, Takeda; DSMB-Cellularity; Grant/Research Support-Sanofi; Major Stockholder-Caelum Bioscience; Other Financial or Material Support-Karopharm 

Elisabet Manasanch: Advisory Board-BMS, GSK, Janssen Pharmaceuticals, Sanofi; Consultant-Adaptive Biotechnologies; Grant/Research Support-JW Pharma, Merck, Novartis, Quest Diagnostics, Sanofi 

Tomer Mark: Advisory Board-Adaptive Biotechnologies, Genentech, Takeda; Consultant-Adaptive Biotechnologies, Amgen, Karypharm 

María-Victoria Mateos: Advisory Board-AbbVie, Adaptive, Amgen, Celgene/BMS, GSK, Janssen, Oncopeptides, Sanofi, Takeda; Speakers Bureau-Amgen, Celgene/BMS, Janssen, Speakers Bureau; Speaker-AbbVie, Adaptive, GSK, Oncopeptides, Sanofi 

Joseph Mikhael: Consultant-Amgen, Celgene, GSK, Janssen, Karyopharm, Sanofi, Takeda 

Nikhil Munshi: Consultant-AbbVie, Adaptive, Amgen, BeiGene, BMS, Celgene, Janssen, Karyopharm Oncopep, Inc., Takeda; Major Stockholder-Oncopep, Inc., OwnershipOncopep, Inc.

Ruben Niesvizky: Consultant-Amgen, BMS, Celgene, GSK, Janssen, Karyopharm, Takeda


North American Center for Continuing Medical Education (NACCME) complies with the legal requirements of the Americans with Disabilities Act and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please call 609-371-1137.


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Copyright © 2020 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education.


Any participant wanting to file a grievance with respect to any aspect of a continuing education activity accredited by NACCME, LLC may contact Samantha Conforti, Manager, Accreditation and Compliance, by phone at 609-371-1137, by email at or in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Manager, Accreditation and Compliance will review the grievance and respond within 30 days of receiving the complaint. If the participant is unsatisfied with the response, an appeal to the Senior Manager/Director or the Executive Vice President, Chris Bolwell, Accreditation and Compliance, can be requested for a second level of review. Mr. Bolwell can be contacted via phone at 678-242-0801, by email at or in writing at 11675 Rainwater Drive, Suite 600 Alpharetta, GA 30009.