Pursuing a Gut Feeling: Exploring Immune Cell Trafficking Inhibitors to Treat IBD

Pursuing a Gut Feeling: Exploring Immune Cell Trafficking Inhibitors to Treat IBD

On-Demand Webcast

What is the role of immune cell trafficking in inflammatory bowel disease (IBD) pathogenesis? How do therapies that modulate immune cell trafficking compare with other agents that target the inflammatory response in IBD, especially with respect to their mechanisms of action? Join Dr. Rubin and Dr. Long as they review these points as well as the latest clinical evidence for current and emerging therapies that target immune cell trafficking to improve outcomes in patients with moderate to severe IBD.



David T. Rubin, MD, FACG
Joseph B. Kirsner Professor of Medicine
Section Chief, Gastroenterology, Hepatology and Nutrition
Inflammatory Bowel Disease Center
University of Chicago Medicine
Chicago, Illinois


Millie D. Long, MD, MPH, FACG
Associate Professor of Medicine
Director, Gastroenterology and Hepatology Fellowship Program
Vice-Chief for Education
University of North Carolina at Chapel Hill
Division of Gastroenterology and Hepatology
Chapel Hill, North Carolina

This continuing medical education activity is provided by North American Center for Continuing Medical Education (NACCME) and Imedex.

For questions regarding this educational activity, please call 609-371-1137 or email info@naccme.com.

Educational Partner: Vindico Medical Education


The intended audience for this activity is gastroenterologists and other health care professionals involved in the management of patients with inflammatory bowel disease (IBD).


Upon successful completion of this activity, participants should be better able to:

  • Review the role of immune cell trafficking in the pathogenesis of IBD
  • Compare the mechanism of action of immune cell trafficking inhibitors to other therapeutics that target the inflammatory response in IBD
  • Evaluate new evidence about currently available and emerging immune cell trafficking inhibitors that may improve outcomes in patients with moderate to severe ulcerative colitis and Crohn’s disease

To be eligible for credit, participants must complete the online activity and the evaluation. Upon completing the activity, there will be instructions on how to complete the evaluation and print a certificate or other documentation of credit.

Release Date: March 2, 2021
Expiration Date: March 1, 2022 
Estimated Time to Complete: 0.75 hours

There is no fee associated with this activity.


This activity is supported by an educational grant from Genentech, Inc.



In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


NACCME designates this internet enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


This continuing nursing education activity awards 0.75 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 0.75 contact hours. 


American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 CreditTM from organizations accredited by the ACCME.


This internet enduring, knowledge-based activity (Universal Activity Number: JA0006201-9999-20-236-H01-P) has been approved for a maximum of 0.75 contact hours (.075 CEUs).

The certificate is not the official record of your participation in the activity. The official record of credit will be the information in the CPE Monitor system. Following ACPE Policy, NACCME must transmit your claim to CPE Monitor within 60 days from the date you complete this CPE activity. NACCME is not able to report your claimed credit after this 60-day period. Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 0.75 AAPA Category 1 credit(s). PAs should only claim credit commensurate with the extent of their participation.


This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of NACCME.


The material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither NACCME nor any of its subsidiaries or affiliates is affiliated with, or formally endorsed by a medical society.

The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME, Vindico or HMP. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.


NACCME, LLC is an independent provider(s) of continuing medical education. NACCME, LLC has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

NACCME, LLC assures that all educational materials are reviewed to ensure for the absence of commercial bias, fair balance, scientific objectivity, and levels of evidence. The educational activity will not be influenced by commercial organizations and will not conflict with any other scheduled educational activities.

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

Planning Committee

In addition to the faculty listed below, NACCME planners and staff include Samantha Conforti, Lara Gray, Damon Harper, Mary Johnson, Kathleen Hines, Randy Robbin and Greaton Sellers. 

Christopher Bolwell: Shareholder: GlaxoSmithKline.

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose.

All planning committee members have disclosed no relevant financial relationships with any commercial interest.


The faculty have reported the following:

Millie Long: Advisory Board-Janssen; Advisory Committee/Board Member-UCB, Inc.; Consultant-AbbVie, Genentech, Janssen, Pfizer, Prometheus, Salix, Takeda, Target PharmaSolutions; Grant/Research Support-Pfizer, Takeda

David Rubin: Advisory Board-American College of Gastroenterology; Consultant-AbbVie, Abgenomics, Allergan, Biomica, Boehringer Ingelheim, Ltd, BristolMyers Squibb, Celgene Corp, CheckCap, Dizel Pharmaceuticals, GalenPharma/Atlantica, Genentech/Roche, Gilead Sciences, GSK, Ichnos Sciences S.A., InDex Pharmaceuticals, Janssen Pharmaceuticals, Lilly, Narrow River Management, Pfizer, Prometheus Laboratories, Reistone, Shire, Takeda, Techlab; Co-Founder-Cornerstones Health, Inc., GoDuRn, LLC; Grant/Research Support-AbbVie, Genentech/Roche, Janssen Pharmaceuticals, Prometheus Laboratories, Shire, Takeda; Stockholder/Ownership Interest-Abgenomics, Biomica

Vindico Medical Education staff have no relevant financial relationships to report.


North American Center for Continuing Medical Education (NACCME) complies with the legal requirements of the Americans with Disabilities Act and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please call 609-371-1137.


NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint providers. NACCME and our joint providers will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting purposes to the appropriate accrediting agency. NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2021 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education.


Any participant wanting to file a grievance with respect to any aspect of a continuing education activity accredited by NACCME, LLC may contact Samantha Conforti, Manager, Accreditation and Compliance, by phone at 609-371-1137, by email at sconforti@naccme.com or in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Manager, Accreditation and Compliance will review the grievance and respond within 30 days of receiving the complaint. If the participant is unsatisfied with the response, an appeal to the Associate Director, Greaton Sellers,  Accreditation and Compliance, can be requested for a second level of review. Mr. Sellers can be contacted via phone at 609-371-1137, by email at gsellers@naccme.com or in writing at 104 Windsor Center Drive, East Windsor, NJ 08520.