New Immunological Approaches to Myeloma: CAR T-Cell Therapy and Other Novel Strategies

New Immunological Approaches to Myeloma: CAR T-Cell Therapy and Other Novel Strategies

On-Demand Webcast

James R. Berenson, MD
Institute for Myeloma and Bone Cancer Research
West Hollywood, California

Adam D. Cohen, MD
Abramson Cancer Center
University of Pennsylvania
Philadelphia, Pennslyvania

Deepu Madduri, MD
Mount Sinai Hospital
New York, New York

Sham Mailankody, MBBS
Memorial Sloan Kettering Cancer Center
New York, New York

Target Audience

This activity is intended for hematologists/oncologists, PAs, NPs, nurses, and pharmacists who specialize in hematology, as well as other HCPs who care for patients with hematologic malignancies.


In 2019 in the United States, ~32,110 people are expected to be diagnosed with multiple myeloma (MM). MM is a challenging disease, however, a host of novel and investigational agents are poised to address this challenge through the targeting of MM-specific antigens. These therapies, including CAR T-cell therapy, have the potential to significantly affect outcomes among patients with MM, but come with their own set of unique clinical challenges, including the management of discrete adverse events (AEs) and patient selection.

This webcast aims to fill the gaps surrounding new antigen targets in MM, identifying appropriate patients for CAR T-cell therapy, and managing toxicities related to CAR-T cell therapy.


Upon successful completion of this educational activity, participants should be better able to:

  1. Describe antigen targets in MM and investigational targeted strategies such as ADCs and BiTEs
  2. Summarize safety and efficacy data from clinical trials regarding current and emerging CAR T-cell therapy interventions for lymphomas and MM
  3. Identify appropriate candidates for CAR T-cell therapy and apply patient referral strategies to support therapeutic application
  4. Develop management strategies for neurologic toxicities and AEs associated with CAR T-cell therapy

Release Date: December 31, 2019

Expiration Date: December 31, 2020

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to


Supported by an educational grant from: Celgene Corporation 


 In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. 


NACCME designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 1.5 AAPA Category 1 credit(s).

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 1.5 contact hours.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.5 contact hours.


This knowledge-based activity (JA0006201-9999-20-041-H01-P) is approved for 1.5 contact hours (0.15 CEUs) of continuing pharmacy education.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact the Manager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Planning Committee

The planning committee comprises James R. Berenson, MD, Adam D. Cohen, MD, Deepu Madduri, MD, Sham Mailankody, MBBS; and Chris Bolwell, Lara Gray, and Griselda Zuccarino-Catania Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant financial relationships that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve any conflicts. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

James R. Berenson, MD, reports that he is a consultant for James R. Berenson MD Inc.; has received grant or research support from IMBCR; and is a speaker for James R. Berenson MD Inc.

Adam D. Cohen, MD, reports that he is a consultant for Celgene, GlaxoSmithKline, Janssen, Kite Pharma, Oncopeptides, Seattle Genetics, and Takeda; has received grant or research support from Novartis; and has received other financial support from Novartis.

Deepu Madduri, MD, reports that she is a consultant for Abbvie, Celgene, Janssen, and Takeda.

Sham Mailankody, MBBS, has received grant or research support from Celgene, Janssen, and Takeda.

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Griselda Zuccarino-Catania disclosed that her spouse is employed by Janssen Pharmaceuticals, Inc.

Lara Gray disclosed no relevant financial relationships with any commercial interests.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of NACCME or Imedex.

Privacy Policy

NACCME and Imedex protect the privacy of personal and other information regarding participants, educational partners, and joint providers. NACCME, Imedex and our joint providers will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

NACCME and Imedex maintain physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2019 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.