Advances in TKI Therapy for CML: Navigating the Future Treatment Landscape

Advances in TKI Therapy for CML: Navigating the Future Treatment Landscape

On-Demand Webcast

Gail J. Roboz, MD
Weill Cornell Medicine
New York, New York


Pinkal Desai, MD
Weill Cornell Medicine
New York, New York

Sangmin Lee, MD
Weill Cornell Medicine
New York, New York

Koen van Besien, MD, PhD
Weill Cornell Medicine
New York, New York

Target Audience

This activity is intended for hematologists/oncologists, PAs, NPs, nurses, and pharmacists who specialize in hematology, as well as other HCPs who care for patients with hematologic malignancies.


Chronic myeloid leukemia (CML) is a malignant disorder of hematopoietic stem cells, accounting for 15-20% of all leukemia cases in adults. The median survival rate has improved significantly in recent years with the advent of TKIs and is expected to reach normal life expectancy for most patients. The primary goals of CML treatment are to prevent progression of the disease by reducing the number of Ph1-positive cells, increase overall survival, and improve the quality of life. Challenges surrounding CML treatment remain, including monitoring patient response, patient adherence, safe discontinuation, and minimizing toxicities. CML treatment decisions are often complex and conflicting. Recently updated NCCN guidelines are stringent and have updated the TKI discontinuation recommendation criteria. The ability to recognize and appropriately manage TKI-associated toxicities can significantly impact patient outcomes, however; it should be understood that management of adverse events should not compromise treatment goals including achieving an antileukemic effect and minimizing disease-related mortality. 

This webcast aims to fill the gap on current treatment updates and guiding clinical-decision making as newer treatments become available for patients with CML.


Upon successful completion of this educational activity, participants should be better able to:

  1. Identify the challenges of current TKI treatment approaches toward CML and strategies to optimize care
  2. Outline the recently updated NCCN guideline criteria that qualifies patients for TKI discontinuation and associated risks

Release Date: December 20, 2019

Expiration Date: December 20, 2020

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to


Supported by an educational grant from: Pfizer Inc.


 In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. 


NACCME designates this live activity for a maximum of 0.75 AMA PRA Category 1 Credits™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 0.75 AAPA Category 1 credit(s).

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 0.75 contact hours.


This knowledge-based activity (JA0006201-9999-20-037-H01-P) is approved for 0.75 contact hours (0.075 CEUs) of continuing pharmacy education.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact the Manager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Planning Committee

The planning committee comprises Pinkal Desai, MD, Sangmin Lee, MD, Gail J. Roboz, MD, Koen van Besien, MD, PhD; and Chris Bolwell, Lara Gray, and Griselda Zuccarino-Catania Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevareports that he has nothing to disclose in relation to this activity.nt commercial companies related to this activity. All relevant financial relationships that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve any conflicts. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Pinkal Desai, MD, reports that she is a consultant for Celgene and Sanofi.

Sangmin Lee, MD, reports that he is a consultant for AstraZeneca Pharmaceuticals, Helsinn, Jazz Pharmaceuticals, Inc, Karyopharm Therapeutics Molecular Systems, and Roche; and has received grant or research support from AI Therapeutics.

Gail J. Roboz, MD, reports that she is a consultant for AbbVie, Actinium, Agios, Amphivena, Argenx, Astex Astellas, Bayer, Celgene, Celltrion, Daiichi Sankyo, Eisai, Janssen, Jazz, Novartis MEI Pharma, Orsenix, Otsuka, Pfizer, Roche/Genentech, Sandoz, Takeda, and Trovagene; and has received grant or research support from Cellectis.

Koen van Besien, MD, PhD, reports that he has nothing to disclose in relation to this activity.

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Griselda Zuccarino-Catania disclosed that her spouse is employed by Janssen Pharmaceuticals, Inc.

Lara Gray disclosed no relevant financial relationships with any commercial interests.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of NACCME or Imedex.

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NACCME and Imedex protect the privacy of personal and other information regarding participants, educational partners, and joint providers. NACCME, Imedex and our joint providers will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

NACCME and Imedex maintain physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2019 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.