Personalized Approach to IBD: Treating to Target With New and Emerging Therapies

Personalized Approach to IBD: Treating to Target With New and Emerging Therapies

On-Demand Webcast

Russell D. Cohen, MD
University of Chicago Medicine
Chicago, Illinois


Stephen B. Hanauer, MD
Northwestern Medicine
Chicago, Illinois

Miguel D. Regueiro, MD
Cleveland Clinic
Cleveland, Ohio

Target Audience

This educational activity is designed and certified for the entire IBD healthcare team and includes education for gastroenterologists, pediatric gastroenterologists, surgeons, physicians, PhDs, researchers, pharmacists, nurse practitioners, physician assistants, gastroenterology nurses, and residents/fellows/students.


The therapeutic landscape in inflammatory bowel disease (IBD) is undergoing a transformation, with the emergence of targeted therapies enabling a shift towards objective treatment goals and individualized care. In contrast to the traditional step-care approach focused on symptom alleviation, the goal of IBD treatment is increasingly focused on achieving objective endpoints such as clinical remission and mucosal healing (MH). This more aggressive top-down approach to management has significantly improved patient outcomes, but also renders clinician assessment of the risk/benefit profile of a given treatment for a given patient essential. However, between- and within-class distinctions in the mechanism of action, efficacy, and safety of new and emerging targeted therapies and their evolving clinical data pool creates a knowledge gap with respect to informed therapeutic selection and sequencing for an individual patient. For optimal IBD patient care, clinicians must have a thorough understanding of the clinical data and latest guideline recommendations surrounding a diverse array of new and emerging therapies in order to bring a personalized approach to the management of IBD.


Upon successful completion of this educational activity, participants should be better able to:

  1. Identify current diagnostic and therapeutic challenges that contribute to suboptimal outcomes in IBD
  2. Apply evidence-based monitoring, diagnostic, and treat-to-target strategies to the management of patients with IBD
  3. Discuss the benefits and limitations of approved IBD pharmacotherapies, including immunomodulatory agents and targeted biologics
  4. Describe the mechanisms of action and available efficacy and safety data surrounding emerging therapeutic classes in IBD, including JAK inhibitors
  5. Integrate the latest clinical data and guideline recommendations into personalized therapeutic strategies for the management of IBD

Release Date: February 14, 2020

Expiration Date: February 14, 2021

Hardware/Software Requirements

The evaluation is accessible after the activity via a PC (Windows 7 or newer) or Mac (Mac OS 10.6 or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications. Please direct technical questions to


This symposium is supported by an educational grant from Gilead.


 In support of improving patient care, this activity has been planned and implemented by North American Center for Continuing Medical Education (NACCME) and Imedex. NACCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. 


NACCME designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.


NACCME has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with the AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 credit(s).

PAs should only claim credit commensurate with the extent of their participation.


This continuing nursing education activity awards 1.0 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.0 contact hour.


This knowledge-based activity (JA0006201-9999-20-086-H01-P) is approved for 1.0 contact hour (0.1 CEU) of continuing pharmacy education.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact the Manager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Planning Committee

The planning committee comprises Russel Cohen, MD, Stephen B. Hanauer, MD, Miguel D. Regeiro, MD; and Chris Bolwell, and Lara Gray, Imedex.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME and Imedex, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant financial relationships that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME and Imedex to initiate a mechanism to resolve any conflicts. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Russell D. Cohen, MD, FACG reports that he is a consultant for Abbvie Laboratories, Celgene, Entera Health, Janssen (Johnson & Johnson/Centocor), Pfizer, Sandoz Biopharmaceuticals, Takeda, and UCB Pharma; has received grant or research support from AstraZeneca, Celgene, Gilead Sciences, Medimmunce, Mesoblast Ltd., Osiris Therapeutics, Pfizer, Receptos, RedHill Biopharma, Sanofi-Aventis, and UCB Pharma; and is a member of the Speaker’s Bureau for Abbvie and Takeda.

Stephen B. Hanauer, MD, FACG reports his is a consultant for Abbvie, Allergan, Amgen, Arena, BMS, Boehringer-Ingelheim, Cellgene, Janssen, Genentech, Gilead, GSK, Merck, Shire, Pfizer and Takeda; that he has provided grant/research support for Abbvie, Allergan, Janssen, Genentech, Gilead, Pfizer and Takeda; and is on the Speakers' Bureau for Abbvie Janssen, Pfizer, and Takeda 

Miguel D. Regueiro, MD, FACG reports he is a consultant for Abbvie, Janssen, UCB, Takeda, Pfizer, Miraca Labs, Amgen, Celgen and Seres and has provided grant/research support from Abbvie, Janssen, UCB, Takeda, Pfizer, Miraca Labs, Amgen, Celgen and Seres

Chris Bolwell discloses that he holds shares of stock of GlaxoSmithKline.

Manjusha Sala disclosed no relevant financial relationships with any commercial interests.


This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters or moderators and do not necessarily reflect the opinions of NACCME or Imedex.

Privacy Policy

NACCME and Imedex protect the privacy of personal and other information regarding participants, educational partners, and joint providers. NACCME, Imedex and our joint providers will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

NACCME and Imedex maintain physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2019 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.