Chronic Wounds: The Roles of MMPs, Reactive Oxygen Species, and Bacteria on Inflammation

On-Demand Webcast

Faculty

William Marston, MD
Chief, Division of Vascular Surgery
Professor, Department of Surgery
Division of Vascular Surgery
UNC Department of Surgery
University of North Carolina
Chapel Hill, North Carolina

Gregory Schultz, PhD
UF Research Foundation Professor
Department of Obstetrics and Gynecology
Institute for Wound Research
University of Florida
Gainesville, Florida

Intended Learners

This activity is designed for physicians, podiatrists, physical therapists, and nurses involved in the management of chronic wounds.

Learning Objectives

After completing this activity, participants should be able to:

Review the phases of the inflammatory reaction in wound healing, including the roles of cellular types, bacteria, cytokine signals, proteases, and reactive oxygen species (ROS)
Describe the normal process of reactive oxygen species production, consequences of ROS overproduction, or when there is impaired detoxification of ROS in wound healing
Discuss factors contributing to the pathogenesis of chronic inflammation, such as macrophage functions and protease/cytokine levels
Implement treatment strategies shown to clinically improve wound healing in the setting of chronic inflammation

Activity Overview

This on-demand webcast is available with synchronized slides and audio.

To be eligible for documentation of credit, participants must complete the educational activity, complete the 10-question online post-test with a score of 70% or better, and complete the evaluation form. After successful completion of the post-test and evaluation form online at www.naccme.com, participants may immediately print their documentation of credit.

Release Date: August 31, 2011
Expiration Date: August 31, 2012
Estimate time to complete: .75 hour

There is no fee associated with this activity.

For questions regarding this activity, please call 609-371-1137.

Hardware/Software Requirements

All educational activities are accessible via a computer with 650 MHz PC, 128 MB RAM, Windows or MAC operating system, Internet Explorer, Netscape, or Safari browsers. Windows Media Player, sound card, and speakers are required for streamed audio. Flash Player, sound card, and speakers are required for video programs. A PDF reader is required for print publications. Please direct technical questions to webmaster.

Accreditation

In support of improving patient care, North American Center for Continuing Medical Education, LLC (NACCME) is accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

CME

NACCME designates this enduring material for a maximum of .75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CNE

This continuing nursing education activity awards .75 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for .75 contact hour.

CPME Accreditation

North American Center for Continuing Medical Education, LLC (NACCME) is approved by the Council on Podiatric Medical Education as a sponsor of continuing education in podiatric medicine.

This program is approved for .75 continuing education contact hour or .075 CEU.

PT Accreditation

This course has been approved by the Texas Board of Physical Therapy Examiners as meeting continuing competency requirements for PTs and PTAs (51516A); the Illinois Physical Therapy Association ( 289-3957); the California Physical Therapy Association (11-478); the Ohio Physical Therapy Association (11S1446) and the Florida Physical Therapy Association (CE110017543). Accreditation of this course does not necessarily imply the FPTA supports the views of the presenters or sponsors.

Independent Clinical Reviewer: Robert S. Kirsner, MD, PhD, Miller School of Medicine, University of Miami, Miami, Florida.

Nurse Planner: Susie Seaman, NP, Sharp Rees-Stealy Wound Clinic, San Diego, California

Planning Committee

The planning committee comprises Robert S. Kirsner, MD, PhD; William Marston, MD; Gregory Schultz, PhD; Susie Seaman, NP; Kristin Ciszeski, Tiffney Oliver, Randy Robbin, and John Savage, NACCME.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are indentified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

The faculty has reported the following:

Dr. Marston: Consultant—Healthpoint, Spiracur; Scientific advisor—Aastrom

Dr. Schultz: Grant/research support—Healthpoint, Kinetic Concepts, Smith & Nephew; Consultant—Life Cell, Suwelack Skin Care; Scientific advisor—Excaliard Pharmaceuticals, Kinetic Concepts, Nanotherapeutics, QuickMed Technologies; Promotional speakers bureau—Smith & Nephew; Stock shareholder—Biosara, Excaliard Pharmaceuticals, QuickMed Technologies; Board member—Biosara, QuickMed Technologies

Dr. Kirsner: Grant/research support—Advanced Biohealing, Healthpoint, Healor, National Institutes of Health, Synovis; Consultant—MoInlycke, National Healing Corporation; Scientific advisor—Organogenesis; Promotional speakers bureau—Advanced Biohealing, Organogenesis

Ms. Seaman: Scientific Advisor—Molnlycke; Promotional Speakers' Bureau—Molnlycke

Ms. Ciszeski, Mr. Robbin, Ms. Oliver, and Mr. Savage have disclosed no relevant financial interests with any commercial interests.

NACCME requires faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.
The faculty disclosed that the following off-label/unapproved use(s) of drugs and/or devices will be discussed: doxycycline for the topical and systemic treatment of chronic wounds.

NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. NACCME and our joint sponsors will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate reporting agency.

NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.
Copyright © 2011 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing medical education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education.

Grant Support

Supported by an educational grant from Derma Sciences, Inc.